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CyFlow™ CD2 Low Endotoxin

110,00 SEK*

Prices net excl. VAT, plus applicable shipping costs

Antigen:	CD2
Alternative Name:	LFA-2
Clone:	TS1/8
Application:	Flow cytometry, Functional assays
Format/Fluorochrome:	Low Endotoxin
Target Species:	Human
Field of Interest:	Immunophenotyping
Species of Origin:	Mouse
Regulatory Status:	RUO
Clonality:	monoclonal
Isotype:	IgG1

HLDA Workshop	HLDA V—WS Code S025
Concentration Unit	mg/mL
Concentration	1
Quantity	0.1 mg
Volume	0.1
Immunogen	Cytotoxic T lymphocytes
Background Information	CD2 (LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
Storage Buffer	The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
Storage	Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Stability	Do not use after expiration date stamped on vial label.

Specific References

| Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA: Three distinct antigens associated with human T‑lymphocyte‑mediated cytolysis: LFA‑1, LFA‑2, and LFA‑3. Proc·Natl·Acad·Sci·USA. 1982·Dec; 79(23):7489‑93. <·PMID:·6984191·> | Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH: Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD‑2 and LFA‑3 antigens. J·Immunol. 1987·Jan·15; 138(2):358‑63. <·PMID:·3098838·> | Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non‑macrophage derived tumours in cytological specimens. J·Clin·Pathol. 1993·Apr; 46(4):334‑6. <·PMID:·7684403·> | Zhang B, Dai M, Li QJ, Zhuang Y: Tracking proliferative history in lymphocyte development with cre‑mediated sister chromatid recombination. PLoS·Genet. 2013·Oct; 9(10):e1003887. <·PMID:·24204301·>

Available Technical Data Sheets

CyFlow™ CD2 Low Endotoxin (TS1 ' 8) CK864668 TDS (US)